Green Synthetized Selenium Nanoparticles Using Syzygium aromaticum (Clove) Extract Reduce Pentylenetetrazol-Induced Epilepsy and Associated Cortical Damage in Rats

We aimed to investigate the potential anticonvulsant effect of green synthetized selenium nanoparticles (SeNPs) using Syzygium aromaticum extract (SAE) (SAE-SeNPs) against epileptic seizures and cortical damage induced by pentylenetetrazole (PTZ) injection in rats its mechanism. A total 84 were divided into six groups; control, PTZ-exposed group, SAE + PTZ-treated sodium selenite (Na2SeO3) SAE-SeNPs diazepam group. significantly increase (p < 0.05) latency time reduce both seizure duration death rate, which enhanced PTZ injection. counteracted PTZ-induced changes oxidants antioxidants. Furthermore, restored pro-inflammatory cytokines (interleukin-1β, interleukin-6, tumor necrosis factor-α) their normal levels suppressed activity glial fibrillary acidic protein showing inhibitory on epilepsy-associated inflammation. In addition, reduced cell apoptosis, as revealed a reduction pro-apoptotic Bax caspase-3 levels, an elevation anti-apoptotic Bcl-2 level. Moreover, modulate neurotransmitter norepinephrine level acetylcholinesterase enzymatic activity. These data concluded via antioxidant, anti-inflammatory, effects, along with ability neurotransmitters.